Thomas Saint was likely from Burlington County, New Jersey and arrived in Perquimans County, North Carolina by 1760. A Quaker, he relocated  first to Northampton County in 1764 and later to Dobbs County in 1772. He wrote a petition in 1778 to the North Carolina General Assembly regarding some disputed land that he had purchased and had been prevented from filing his claim. In 1781, he signed a petition from the Wayne County Quakers requesting that they reconsider the amounts of taxes levied on the Quakers. Saint returned to Perquimans in 1786 and he was officially removed from the Perquimans Meeting in 1795 following a disagreement. Saint later moved to Fairfield, South Carolina before settling in Bedford County, Tennessee, where he died in about 1830.